Correlation of HOMA-IR and HbA1C with hematological parameters in patient with Diabetes mellitus Type II in Kirkuk city
Abstract
Objective: The aim of this study was to investigate the relationship between hematological parameters and glycemic control in patients with type 2 diabetes mellitus (DM). Materials and Methods: This case-control study included 50 patients with DM and 50 healthy controls. Blood samples were collected from all participants to measure various hematological parameters and serum glucose, insulin, and HbA1c levels. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) was calculated to evaluate insulin resistance. Statistical analysis was performed to compare the results between the groups and to determine the correlation between hematological parameters and glycemic control. Results: The results showed that serum glucose, insulin, HbA1c, serum potassium, RDW, platelet count, and MID were significantly increased in the DM group compared to the control group, while MCV was significantly decreased. The correlation analysis showed that MID, platelet count, PCT count, and PDW were positively correlated with serum glucose, HbA1c, and HOMA-IR, while MCV was negatively correlated with serum glucose and HbA1c. RBC count, RDW, and PCV were positively correlated with HbA1c and HOMA-IR. Conclusions: The study found that DM type II patients had elevated serum glucose, insulin, HOMA IR, and HbA1C levels, as well as increased serum potassium and MID-range absolute count, and decreased MCV but increased RDW. Platelet count, PCT count, and PDW were positively correlated with serum glucose, HbA1C, and HOMA IR. These hematological parameters may serve as useful markers for assessing glycemic control and insulin resistance in DM type II patients.
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